Omeprazole & Esomeprazole do not increase risks of heart disease
Preliminary findings from a review of safety data found that Omeprazole (Prilosec and Zegerid) and Esomeprazole (Nexium) may have increased the risk of heart problems. Further review indicated that there is no substantial increase in heart problems when these medicines are used long term. This interpretation is based on two small long-term studies and further research may change this interpretation. Both of these agents are proton pump inhibitors which help reduce stomach acid in gastroesophageal reflux disease (GERD) and peptic ulcer disease (PUD).